Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
Known for shuttling APP, the endosomal receptor latches on to tau. Knocking it down in glia reduced tau seeding. The N1358S risk variant ramped it up.
Known for shuttling APP, the endosomal receptor latches on to tau. Knocking it down in glia reduced tau seeding. The N1358S risk variant ramped it up.
First papers from MoTrPAC initiative report myriad responses to endurance training in multiple organs in rats, including the brain and heart.
In the DIAN familial AD prevention trial, plaque-busting antibody gantenerumab, but not monomer-targeting solanezumab, nudged fluid markers toward normal.
Tauopathy cranks up lipid synthesis in neurons, which slip the fats to microglia. Blocking AMP kinase greases this process.
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
Scientists find the senescent subtype has a distinct protein signature, but little change in gene expression, causing it to be overlooked in transcriptomic studies.
Lysosomes deliver a plethora of mRNA transcripts, including those encoding ribosomal subunits and mitochondrial proteins, to axonal terminals for translation.
In a small Phase 2 trial, the GLP-1 analogue lixisenatide stabilized motor abilities over one year in people with early PD.
The neuronal endolysosome system is one of the first to falter in Alzheimer’s disease. What stalls it? C-terminal fragments of amyloid precursor protein disrupting calcium signaling, according to a new study. Cells lacking presenilin 1 and 2 accumulate APP-CTFs in lysosomes at junctions with the endoplasmic reticulum. The CTFs prevent calcium flow from the ER to the lysosome, slowing endolysosomal function.
To support the dynamic demands of neurotransmission, axons require a steady supply of mRNA for local protein synthesis. A new study reports that thousands of these transcripts arrive on lysosomes. If this mode of transport shuts down, local axon translation falters, mitochondria fail, autophagosomes pile up, and axons degenerate.
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